Molecular Basis Of Inheritance Questions

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Molecular Basis Of Inheritance Questions

List of molecular basis of inheritance Questions

Question NoQuestionsClass
1140. In DNA, the linkages between different nitrogenous
bases are
(a) phosphate linkage (b) H-bonding
(c) glycosidic linkage (d) peptide linkage.
NECT
12
2What is a triplet codon?
( A ). Fixed
B. Degenerate
c. Ambiguous
D. Non-wobbly
12
3The backbone of DNA is made up of?
A. Sugar only
B. Lipid and phosphate
C. Protein and phosphate
D. Sugar and phosphate
12
4Define transcription.12
5Choose the wrong statement in the
process of protein synthesis.
A. After uncoiling of DNA molecule, one strand acts as a template for the formation of mRNA.
B. In the presence of DNA polymerase enzyme, the mRNA is formed based on the triplet codes.
C. The mRNA that leaves nucleus reaches cytoplasm and gets attached with 30 S ribosomal subunit
D. The amino acids are transferred from the intracellular amino acid pool to the active ribosomes by the tRNA.
12
6What is transcription?12
7Assertion
Hn ( m R N A ) is larger than ( m R N A )
Reason
Hn ( R N A ) has no translating introns and has more exons than required for translation.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
c. Assertion is correct but Reason is incorrect
D. Both Assertion and Reason are incorrect
12
8133. The correct statement regarding RNA and DNA,
respectively is
(a) the sugar component in RNA is a arabinose and
the sugar component in DNA is ribose
the sugar component in RNA is 2′-deoxyribose
and the sugar component in DNA is arabinose
(C) the sugar component in RNA is arabinose and the
sugar component in DNA is 2′-deoxyribose
(d) the sugar component in RNA is ribose and the
sugar component in DNA is 2′-deoxyribose.
12
9Choose the correct mRNA sequence for
the given DNA sequence.
AGTTCG
A. TCUUGC
B. UCAACG
c. AGTTCG
D. TCAACG
E. UCAAGC
12
10Write any two chemical different
between DNA and RNA.
12
11Antibiotic inhibiting interaction between tRNA and mRNA during protein synthesis in bacteria is
A. Tetracycline
B. Neomycin
c. Erythromycin
D. Streptomycin
12
12Draw a clover leat structure of tRNA
showing the following.
(i) Tyrosine attached to its amino acid site.
(ii) Anticodon for this amino acid in its correct site (codon for tyrosine is UCA)
12
13How is this process of ( m R N A )
synthesis different from that in prokaryotes?
12
14Assertion: In prokaryotes, there are three initiation factors used for protein synthesis.

Reason: All the initiation factors have
their own functions.
A. If both the assertion and the reason are true and the reason is a correct explanation of the assertion
B. If both the assertion and reason are true but the reason is not a correct explanation of the assertion
c. If the assertion is true but the reason is false
D. If both the assertion and reason are false
E. If the assertion is false but reason is true

12
15In one polynucleotide strand of a DNA molecule, the ratio of ( boldsymbol{A}+boldsymbol{T} / boldsymbol{G}+boldsymbol{C} ) is
0.3. What is the ( boldsymbol{A}+boldsymbol{G} / boldsymbol{T}+boldsymbol{C} ) ratio of
the entire DNA molecule?
A . 0.3
B. 0.6
c. 1.2
D.
12
16The structure of DNA and RNA are
similar in that
A. Both molecules are made of the same 5 carbon sugar.
B. Both molecules are composed of the same four nitrogenous bases.
C. The nucleotides of both molecules contain a
phosphate group.
D. Both molecules are double stranded which are antiparallel in directionality.
12
17Name the transcriptionally active region of chromatin in a nucleus.12
18Which of the following is translated completely?
I. AUG, UGA, UUA, AAG, AAA
II. AUG, AUA, UUG, CCC, UGA
III. ( A G U, U C C, A G A, C U C, U A A )
IV. AUG, UAC, AGU, AAC, UAG
A. I and II
B. II and IV
c. I and IV
D. II and III
12
19Amino acid sequence, in protein synthesis is decided by the sequence of which one of the following?
( A cdot ) cDNA
B. rRNA
( c cdot operatorname{tRNA} )
D. mRNA
12
20(a) Name the enzyme responsible for the transcription of tRNA and the amino
acid the initiator tRNA gets linked with.
(b) Explain the role of initiator tRNA in initiation of protein synthesis.
12
21According to lac operon concept, an
operator gene combines with
A. Co-repressor to switch off transcription of structural gene
B. Inducer gene to switch on structural gene transcription
C. Repressor gene to switch off transcription of structural gene
D. Regulator protein to switch on structural gene transcription
E. Regulator protein to switch off structural gene transcription
12
22A student is given two samples of nucleotides. One sample contains DNA nucleotides and the other sample contains RNA nucleotides, but the two samples have not been labeled.
What information would assist the
student in identifying which sample contained the DNA nucleotides versus
the RNA nucleotides?
A. The sugar in DNA nucleotides contains six carbon atoms and the sugar in an RNA molecule contains five carbon atoms.
B. The sugar in DNA nucleotides is an aldehyde sugar anc the sugar in RNA nucleotides is a ketone sugar
c. The sugar in DNA nucleotides contains one less oxyger atom than the sugar in RNA nucleotides
D. The sugar in DNA nucleotides is in the alpha configuration and the sugar in RNA nucleotides is in the beta configuration
12
23Among the nitrogenous base involved in DNA and RNA formation, which is the
double ring base?
A. Uracil
B. Guanine
c. Thymine
D. Cytosine
12
24What are termination codons?12
25Define a gene?12
26In the DNA molecule
A. The proportion of adenine in relation of thymine varies with the organism.
B. There are two strands which run antiparallel one in ( 5^{prime} ) ( rightarrow 3^{prime} ) direction and other in ( 3^{prime} rightarrow 5 )
C. The total amount of purine nucleotides and pyrimidine nucleotides is not always equal.
D. There are two strands which run parallel in the ( 5^{prime} rightarrow 3^{prime} ) direction.
12
27Nucleosome core is intimately associated with
A . 160 bp DNA
B. 210 bp DNA
c. 250 bp DNA
D. 100 pp DNA
12
28The DNA model proposed by Watson and
Crick
A. combined many of the findings of other researches also studying DNA such as Rosalind Franklin and Chargaff.
B. showed the double helix nature of the molecule
C. presented a molecule with sugar-phosphate backbones on the outside and paired bases on the inside
D. all of the above
12
29Describe the interaction of ( t-R N A, m )
RNA and ribosomes during the events of translation.
12
30The ( 3^{prime}-5^{prime} ) phosphodiester linkages inside a polynucleotide chain serve to join
A. one nucleotide with the another nucleotide
B. One nucleoside with another nucleoside
c. one deoxyribose sugar with another nucleoside
D. One nitrogenous base with pentose sugar
12
31During transcription, holoenzyme RNA polymerase binds to DNA sequence and DNA assumes a saddle like structure at
that point. The sequence is called as
( A ). AAAT box
B. TATA box
( c cdot operatorname{GGCC} ) box
D. CAAT box
12
32The first amino acid formed during
translation
A. Occupies the aminyl site first, then the peptidyl site
B. Occupies the aminyl site before the attachment of the large portion of the ribosome
C. Of the polypeptide chain is methionine
D. All of the above
E. None of the above
12
33A eukaryotic gene contains two kinds of base sequences.Which of these plays an important role in protein synthesis?
A. Introns
B. Exons
c. Both A and B
D. None of the above
12
34The two polynucleotide chain in DNA
are:
A. Semiconservative
B. Parallel
c. Discontinuous
D. Antiparallel
12
35Which of the following amino acid has hydroxyl methyl group as its R group?
A. Serine
B. Proline
c. Alanine
D. Arginine
12
36Which of the following enzyme is used to join DNA fragments?
A. Terminase
B. Endonuclease
c. Ligase
D. DNA polymerase
12
37Which of the following is an initiation codon?
A . AUGGGGGGGGG ( . ) GGGGG
B. UAG
c. UGA
D. UAA
12
38In Lac operon if a mutation occurs in
the middle gene of the structural genes
then
A. ( beta ) – galactosidase will not be synthesised
B. Permease will not be synthesised
c. Transacetylase will not be synthesized
D. Lactose digestion will be rapid
12
39The transcription unit extends from
A. TATA box to start point
B. TATA box to stop codon
C . Start point to stop codon
D. 35 sequence to start point
12
40How many among the following organisms hve linear ds DNA as their
genetic material? Homo sapiens, Escherichia coil Drosophila, ( phi times 174 ) bacteriophage
A . 1
B. 4
( c .3 )
D.
12
41Match the enzyme in column I with its
function in column II.
12
42Transfer of DNA bands from an agarose
gel to a nitrocellulose or nylon membrane is referred to as
A. western transfer
B. Northern transfer
c. Eastern transfer
D. Gene transfer
E. Southern blotting
12
43Watson and Crick were awarded Nobel
Prize for their finding of
A. RNA is single stranded
B. DNA is double stranded
c. DNA is genetic material
D. DNA guides mRNA synthesis
12
44What is the process of joining together different DNA fragments often referred as?
A. Transcription
B. Cloning
c. Gene splicing
D. DNA amplification
12
45Protein synthesis commences when
A. mRNA binds to the smaller subunit of Ribosomes
B. mRNA bind to the larger subunit f Ribosome
C. Both smaller and larger sub units binds each other over the mRNA molecule.
D. The adapter RNA recognises the enzymes from cytoplasm.
12
46For the structure of nucleic acid, which
of the following statements is wrong?
A. DNA can be single stranded in some viruses.
B. RNA can be double stranded occasionally.
C. There are as many as 12 bases per turn in Z DNA.
D. The length of one helix is ( 45 AA ) in B-DNA and in Z-DNA.
12
47Transcription means synthesis of
A. DNA
B. Protein
c. mRNA
D. Enzyme
12
48Using the given indicators, construct RNA nucleotide and any one DNA nucleotide.
( G )
hosphat
12
49A DNA molecule that recognizes specific transcription factors that can stimulate transcription of nearby genes is depicted by
A. Promoter
B. Enhancer
c. operator
D. Euchromatin
E. Heterochromatin
12
50The enzyme required for transcription is
A. Restriction enzyme
B. DNA polymerase
c. RNA polymerase
D. RNase
12
51Choose the correct answers from the
alternatives given :
Which of the following regarding DNA is
not true?
A. Complementary base pairs consist of one purine and one pyrimidine
B. Side rails of the DNA double helix are made of alternating molecules of phosphate and ribose
c. complementary base pairs are joined by hydrogen bonds
D. Amount of thymine equals the amount of adening
12
52Choose the correct answer from the
alternatives given. Which of these is mismatched?
A. Post transcriptional control-nucleus
B. Translational control – cytoplasm
c. Transcriptional control – -nucleus
D. Postranslational control – nucleus
12
53Nucleoside is
A. Nitrogenous base + sugar
B. Nitrogenous base + sugar + phosphate
c. sugar + phosphate
D. Nitrogenous base + phosphate
12
54Assertion
Replication and transcription occur in the nucleus but translation occurs in
the cytoplasm.
Reason
mRNA is transferred from the nucleus
into the cytoplasm where ribosomes and amino acids are available for
protein synthesis.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
C. Assertion is correct but Reason is incorrect.
D. Both Assertion and Reason are incorrect.
12
55Histone occupies the major grooves of DNA at an angle of
( A cdot 15^{circ} )
B. ( 90^{circ} )
( mathrm{c} cdot 45^{circ} ) to the helix axis
D. 30 to the helix axis
12
56Genetic information in a DNA molecule
is coded by the
A. Sequence of nucleotides
B. Base pairing
c. Turning pattern of the helix
D. Proportion of each base present
12
57The following ratio is generally constant for a given species :-
( A cdot T+C / G+A )
B. ( G+C / A+T )
c. ( A+C / T+G )
D. A + G / C +T
12
58Who among the following did not provide experimental proof for the semiconservative model of DNA
replication?
A. Meselson & Stahl
B. Cairns
c. Watson & Crick
D. Taylor
12
59Why does synthesis of DNA proceed only
in the ( 5^{prime} ) to ( 3^{prime} ) direction?
A. DNA polymerases can only add nucleotides to the ( 3^{prime} ) end of a polynucleotide strand.
B. The ( 3^{prime} ) end of the polynucleotide molecule is more electronegative than the ( 5^{prime} ) end.
c. This is the direction in which the two strands of DNA unzip
D. The chromosomes are always aligned in the ( 5^{prime} ) to ( 3^{prime} ) direction in the nucleus
12
60Ribose sugar differs from deoxyribose in having
A. two extra oxygen molecules
B. one extra oxygen molecules
c. no oxygen
D. Hydroxyl group
12
61mRNA coded language is known as
A. Cryptogam
B. Cryptoanalysis
c. cryptogram
D. codogens
12
62During protein synthesis in an
organism, at one point the process comes to a halt. Select the group of the three codons from the following from which any one of the three could bring about this halt?
A. UUU, UCC, UAU
B. UUC, UAC
c. UAG, UGA, UAA
D. UUG, UCA, UCG
12
63In a typical DNA molecule, the proportion of thymine is ( 30 % ) of the ( mathrm{N} ) bases. Find out the percentages of other N bases.12
64What acts as an inducer in lac operon? How does it switch on the operon?12
65Transcription is the transfer of genetic
code from a DNA molecule to
A. RNA molecule
B. Second DNA molecule
C. Ribosomal sub unit
D. Sequence of amino acids in a protein molecule
12
66One of these is not associated with
termination of protein synthesis
A. UAA
B. UAG
c. UGA
D. AUGGGGGGGGG
12
67Lactose operon is considered to be glucose sensitive due to
A. Catabolite induction
B. Allosteric inhibition
c. Anabolic inhibition
D. None of the above
12
68The proportion of nucleotides in a given acid are : adenine 18%, Guanine 30%,
Cytosine42 % and Uracil 10 %. Name the
nucleic acid and mention the number of
strands in it.
12
69Join properly Column-I and Column-II.
Column I Column II
( (A) )
(1)
Lysin A) UUU ( 6^{G C} )
(B)
(2)
Stop codon
( (C) )
(3) Phenyl Alanine AAA
(D)
(4)
UAA Glycine ne
( A cdot a-2, b-3, c-4, d-1 )
B. ( a-4, b-3, c-1, d-2 )
c. ( a-1, b-4, c-3, d-2 )
D. ( a-3, b-4, c-1, d-2 )
12
70First codon of uracil nucleotides, UUU was deciphered by
A. Mathaei
B. Khorana
c. Nirenberg
D. Both A and C
12
71Genetic code is a translation of the
language of
A. RNA into that of proteins
B. Proteins into that of RNA
c. Amino acids into that of RNA
D. RNA into that of DNA
12
72Which component is not directly involved in the process known as translation?
A. Ribosomes
B. tRNA
c. DNA
D. mRNA
12
73Antiparallel strands of a DNA molecule
means that
A. One strand turns anti-clockwise
B. The phosphate groups of two DNA strands, at their ends, share the same position.
c. The phosphate groups at the start of two DNA strands are in opposite position (pole).
D. One strand turns clockwise.
12
74DNA separated from one cell,when
introduced into another cell is able to
bestow some of the properties of former to the latter.What is this change called
in technical terms? Describe the
experimental evidences which led to the
discovery of the above phenomenon.
12
75Which one of these substances will
repress the lac operon?
A. Arabinose
B. Glucose
c. Lactose
D. Tryptopham
12
76Choose the correct answers from the
alternatives given :
During protein synthesis, an anticodon on transfer RNA (tRNA) pairs with
A. messenger RNA (mRNA) nucleotide bases
B. ribosomal RNA (rRNA) nucleotide bases
c. other tRNA nucleotide bases
D. DNA nucleotide bases
12
77Explain the double helix structure of DNA with a labelled diagram.12
78Purines possess nitrogen at which
position?
A. 1,2,4 and 6 position
B. 1, 3, 5 and 7 position
c. 1,3,7 and 9 position
D. 1,2,6 and 8 position
12
79Which of the following statements
about histones is not true?
A. Histones are very similar between species
B. Histones have many basic amino acids
C. Histones are rich in lysine and arginine
D. Each histone has one single gene that codes for it
12
80Explain Watson and Crick’s model of
DNA.
12
81Match the columns.
( mathbf{A} )
( a-2, b-3, c-1, d-4 )
B. ( a-1, b-4, c-2, d-3 )
c. ( a-3, b-1, c-4, d-2 )
D. ( a-2, b-4, c-1, d-3 )
12
82Which one of the following statement is
not correct?
During protein synthesis,
A. UAA codon codes for lysine.
B. UGG codon codes for tryptophan.
c. cysteine is coded by UGU and UGC codons.
D. Tyrosine is coded by UAU and UAC
12
83DNA-dependent RNA polymerase catalyze transcription on one strand of the DNA which is called the
A. Alpha strand
B. Antistrand
c. Template strand
D. coding strand
12
84tRNA has the function of
A. Transcription
B. Carrier for attaching amino acids over mRNA template
c. Transferring information to mRNA
D. Carrying genetic code to cytoplasm
12
85The above-given model of t-RNA was
explained by
A. Watson and crick
B. Friedrick meischer
c. Clover leaf
None of the above
12
86Discuss with your teacher and find out how to distinguish between.
(a) Plasmid DNA and Chromosomal DNA
(b) RNA and DNA
(c) Exonuclease and Endonuclease
12
87The number of cytosine bases in a DNA molecule is equal to the number of
bases.
12
88A short length linear double-stranded DNA molecule has 110 thymine and 110 guanine bases. The total number of
nucleotide in the DNA fragment will be
A . 110
B. 880
( c cdot 440 )
D. 220
12
89The process of RNA formation from DNA is called as
A. Transition
B. Translation
c. Transversion
D. Transcription
12
90Given below are the steps of protein synthesis. Arrange them in. correct sequence and select the correct option.
(j) Codon-anticodon reaction between mRNA and aminoacyl tRNA complex.
(ii) Attachment of mRNA and smaller
sub-unit of ribosome.
(iii) Charging or aminoacylation of tRNA.
(iv) Attachment of larger sub unit of ribosome to the mRNA-tRNAMet
complex.
(v) Linking of adjacent amino acids.
(vi) Formation of polypeptide chain.
A ( cdot(text { ii }) rightarrow(i) rightarrow(text { iii }) rightarrow(v) rightarrow(text { iv }) rightarrow(v ) i)
B. (v) ( rightarrow ) (ii) ( rightarrow(text { i) } rightarrow text { (iii) } rightarrow text { (iv) } rightarrow ) (vi)
( c cdot(text { iii) } rightarrow(text { ii) } rightarrow(text { iv }) rightarrow(i) rightarrow(v) rightarrow(v i) )
D. (iii) ( rightarrow(text { ii }) rightarrow(i) rightarrow(text { iv } v rightarrow(v) rightarrow(v i) )
12
91Why is RNA required to undergo splicing?12
92Under electron microscope, chromatin fibres appear like beads in a string. The beads are
A. Chromosomes
B. Nucleosomes
c. Solenoids
D. Chromonemas
12
93A DNA segment has sequence ATC CAT CTA GTA, the sequence of RNA synthesized by this segment is
A. TUG GTU GUT CAU
в. GUT GтU GUT САU
c. сАU ятบ яUт сти
D. UAG GUA GAU CAU
12
94If a triplet on template DNA is AAA, what will be the anticodon on tRNA
A. UUU
B. AAA
c. ( pi T )
D. AUGGGGGGGGGG
12
95Which of the following RNA’s picks up specific amino acid from amino acid pool in the cytoplasm to ribosome during protein synthesis?
( mathbf{A} cdot ) tRNA
B. mRNA
c. rRNA
D. All of the above
12
96Identify the protein with more than one
polypeptide chain.
A. Myoglobin
B. Trypsin
c. Immunoglobulin
D. Lysozyme
12
97State the difference between the
structural gene in a transcription unit
of prokaryotes and eukaryotes.
12
98A smaller subunit of ribosome has a
binding site for ( _{-}–_{-}- ) and the larger subunit has two binding sites for tRNA
molecules.
A ( cdot mathrm{Mg}^{+} )
B. Peptidyl transferase
c. mRNA
D. None of the above
12
99The helical structure of DNA was
discovered by
A. sanger
B. Bloor
c. L.Pauling
D. watson and Crick
12
100Influence of genes in controlling the activity of living organisms is through
A. Vitamins
B. Protein synthesis
c. Photosynthesis
D. Hormones
12
101Initiation codon is
A. UUU
B. UGA
c. AUG
D. UAG
12
102Which of the following is utilized by all living organisms?
A ( cdot C O_{2} )
B. A triplet genetic code to produce proteins
c. oxygen
D. ADP as cellular energy
E. Membrane-bound organelles
12
103List two essential roles of ribosome
during translation.
12
104Formation of RNA on DNA template is called as
A. Transduction
B. Transformation
c. Transcription
D. Translation
12
105The enzyme polynucleotide phosphorylase randomly assembles nucleotides into a polynucleotide phosphorylase to a solution of adenosine triphosphate and guanosine triphosphate, how many types artificial
( m R N A 3 ) nucleotide codons would be
possible?
( mathbf{A} cdot mathbf{3} )
B. 4
c. 8
D. 16
12
106The difference(s) between mRNA and
tRNA is/are that:
(i) mRNA has more elaborate 3
dimensional structure due to extensive
base – pairing
(ii) tRNA has more elaborate ( 3- )
dimensional structure due to extensive
pairing
(iii) tRNA is usually smaller than mRNA
(iv) mRNA bears anticodon but tRNA
has codons
A. (i) and (iii)
B. All of these
c. (ii) and (iii)
D. (i), (ii) and (iii)
12
107Which is most directly responsible for the sequence of amino acids in a protein?
A. Sequence of the anticodons
B. Number of codons in mRNA
c. Proteins associated with rRNA
D. The sequence of codons in mRNA
12
108‘Abirin’ and ‘ricin’ are toxic plant
proteins which inhibit the protein synthesis in eukaryotic ribosomes by inactivating the
A. 40 s subunit
B. 60S subunit
( c cdot 60 s ) and ( 40 S )
D. Genetic code
12
109The process of mRNA synthesis on a DNA is known as
A. Translation
B. Transcription
c. Transduction
D. Transformation
12
110In the light of Watson and Cricks model, describe the detailed structure of DNA.12
111Who proposed the ‘signal hypothesis’ meant for the biosynthesis of secretory
type of proteins?
A. Baltimore
B. Camillio Golgi
c. Blobel and Sabatini
D. Sheeler and Bianchi
12
112Degeneration of genetic code is due to
A. First member of codons
B. Second member of codons
c. Third member of codons
D. Entire codons
12
113Match the following and choose the
correct combination from the options
given.
( begin{array}{llll} & text { Column-I } & & text { Column-II } \ text { A. } & begin{array}{l}text { Walter } \ text { Sutton }end{array} & text { 1. } & begin{array}{l}text { Discovered } \ text { penicillin }end{array} \ text { B. } & begin{array}{l}text { Thomas } \ text { Hunt }end{array} & text { 2. } & begin{array}{l}text { Discovered the } \ text { chromosomal } \ text { basis of heredity }end{array} \ text { D. } & begin{array}{l}text { James } \ text { Watson }end{array} & text { 3. } & begin{array}{l}text { Described the } \ text { phenomenon of } \ text { linkage and } \ text { crossing over }end{array} \ & text { Morgan } & & begin{array}{l}text { Discovered the } \ text { double helical } \ text { structure of DNA }end{array}end{array} )
A. A-1, B-4, C- 2, D-3
B. A- 2, B-3, C-1, D-4
C. ( A-3, B-2, C-1, D-4 )
D. A- 2, B-3, C-4,D-1
E. A- 4, B-1, C-2,
( D )
12
114Ribosomes are sites of which reaction?
A. Respiration
B. Photosynthesis
c. Protein synthesis
D. Fat synthesis
12
115Watson and Crick are credited for the
discovery that DNA
A. Is a double stranded helì
B. Is responsible for the synthesis of tRNA
c. Is a carrier of genetic information
D. Provides proof for the ( x ) -y chromosomal theory of sex determination
12
116The process involved in the RNA
formation on the DNA template is called
as
A. Translation
B. Transduction
c. Transcription
D. Transformaion
12
117Because most of the amino acids
are represented by more than one codons, the genetic code is said to be
A. Deaminated
B. Comma less
c. Degenerate
D. Overlapping
12
118The pitch angle of deflection between
two successive base pairs in DNA double helix is
A ( cdot 20^{circ} )
B. ( 34^{circ} )
( c cdot 36^{circ} )
D. ( 360^{circ} )
12
119Antiparallel strands of a DNA molecule
means that
A. One strand turns clockwise.
B. One strand turns anti-clockwise.
C. The phosphate groups of two DNA strands at their ends share the same position.
D. The phosphate groups at the start of two DNA strands are in opposite position (pole)
12
120During translation, activated amino
acids get linked to (RNA). This process is commonly called as
A. charging of tRNA
B. discharging of tRNA
c. aminoacylation of tRNA
D. both (a) and (c).
12
121DNA is a polymer of nucleotides which
are linked to each other by ( 3-5 ) phosphodiester bond. To prevent polymerisation of nucleotides, which of the following modifications would you choose?
A. Replace purines with pyrimidines.
B. Remove/Replace 3 OH group in deoxyribose.
c. Remove/Replace 2 OH group with some other group in deoxyribose.
D. Both (b) and (c)
12
122B-DNA double helix makes a complete
turn with
A. Every 10 base pairss
B. Every 20 base pairss
C. Every 36 base pairs
D. Every 3-6 base pairs
12
123The promoter site and the terminator
site for transcription are located at
( A cdot 3 ) (downstream) end and 5 (upstream) end, respectively of the transcription unit
B. 5 (upstream) end and 3 (downstream) end, respectively of the transcription unit
C. the 5 (upstream) end
D. the 3 (downstream) end.
12
124Which one of the following combinations is found in DNA ?
A. Guanine and guanidine
B. Guanidine and cytosine
c. Guanine and cytosine
D. Adenine and guanidine
12
125137. The sequence of bases on RNA molecule synthesized
on the GCATA strand of DNA is
(a) CGUAU
(b) CGTAT
(c) TACGC
(d) AYCGC (COMEDK)
12
126(a) Construct a complete transcription unit with promoter and terminator on the basis of the hypothetical template
strand given below:
(b) Write the RNA strand transcribed from the above transcription unit along
with its polarity.
12
127What is aminoacylation? State its significance.12
128(a) Explain the experiment performed by Griffith on Streptococcus pneumoniae. What did he conclude from this
experiment?
(b) Name the three scientists who
followed up Griffiths experiments.
(c) What did they conclude and how?
12
129Method by which information reaches
from DNA to RNA is
A. Transcription
B. Translation
c. Transformation
D. Transduction
12
130What is complementary base pairing?12
131How do histones acquire positive charge?12
132In ATG ACC AGG ACC CCA ACA sequence,
the first base gets mutated. It will affect
A. Change in types and sequence of amino acids
B. Change in first amino acid only
c. No change
D. One amino acid less
12
133Adenine is ( 30 %, ) what would be the
percentage of guanine?
A . 10%
B. 20%
c. 30%
D. 40%
12
134Length of DNA with 23 base pairs is
A . ( 78.4 mathrm{A}^{circ} )
B. 78.2 A ( ^{text {о }} )
( mathbf{c} cdot 78 mathrm{A}^{circ} )
D. 74.8 A
12
135Which one of the following pairs of codons is correctly matched with their function or the signal for the the particular amino acid?
A. AUG, ACG – Start/methionine
B. UUA, UCA – Leucine
c. GUU – Alanine
D. UAG, UGA – Stop
12
136Protein synthesis in an animal cell
occurs
A. Only on the ribosomes present in cytosol
B. On ribosomes present in cytoplasm as well as in mitochondria
C. Only on ribosomes attached to the nuclear envelope and smooth endoplasmic reticulum
D. On ribosomes present in the nucleolus as well as in cytoplasm
12
137Which of the following is the pribnow
box?
A . 5′ TATAAT 3
B. 5′ TAATTAT 3
c. ( 5^{text {‘ }} ) AATAAT ( 3^{text {‘ }} )
D. 5′ ATATTA 3’
12
138In a DNA molecule distance between
two bases is
( mathbf{A} cdot 2 n m / 20 stackrel{circ}{A} )
B ( cdot 0.2 n m / 2 stackrel{circ}{A} )
c. ( 3.4 n m / 34^{circ} )
D. ( 0.34 n m / 3.4^{circ} )
12
139Double-helical structure is found in12
140Teminism is same as
A. Transcription
B. Translation
C. Reverse transcription
D. DNA synthesis
12
141Choose the correct answer from the
alternatives given:
In E. Coli, the lac operon gets switched
on when
A. Lactose is present and it binds to the repressor
B. Repressor binds to operator
C. RNA polymerase binds- to the operator
D. Lactose is present and it binds to RNA polymerase
12
142Portion of gene which is transcribed but not translated is
( A ). Exon
B. Intron
c. cistron
D. codon
12
143A short length of DNA molecule has 80 thymine and 80 guanine bases. The total number of nucleotids in the DNA
fragment is
A ( cdot 160 )
B. 40
( c cdot 80 )
D. 320
E. 640
12
144Where are proteins synthesised inside
the cell?
12
145The codon AUG has dual function. It is
an initiation codon and also codes for
A. Formaldehyde
B. Methionine
c. Phenylalanine
D. serine
12
146Which one of the following codes for an amino acid?
A. Cistron
B. Exon
c. codon
D. Intron
12
147Termination of chain growth in protein synthesis is brought about by
A. UUG, UGC, UCA
B. UCG, GCG, ACC
c. UAA, UAG, UGA
D. UUG, UAG, UCG
12
14867. The central dogma of molecular genetics states that
the genetic information flows from
(a) Amino acids Proteins DNA
(b) DNA-Carbohydrates Proteins
C) DNARNA Proteins
(d) DNA RNA Carbohydrates (NEET Phase-I)
12
149Watson and Crick shared the Nobel
Prize for DNA structure with
A. Franklin
B. Paulingg
c. wilkins
D. Tatum
12
150A DNA molecules measuring ( 680 A^{circ} )
contains
12
151Which of the following genes is not transcribed from the promoter for ( boldsymbol{beta} )
galactosidase?
A . Lac- ( z )
B. Lac-i
c. ( operatorname{Lac}-gamma )
D. Lac-A
12
152Wobble hypothesis deals with
A. Phenomena of multiple codons coding for the code for a single amino acid
B. Phenomena of multiple codons coding for the code for a different amino acid
C. Phenomena of anticodon coding for the code for a different amino acid
D. None of the above
12
153Which site of a tRNA molecule forms
hydrogen bonds with mRNA molecule?
A. codon
B. Anticodon
c. ( 5^{prime} ) end of the t-RNA molecule
D. ( 3^{prime} ) end of the t-RNA molecul
12
154If the total amount of adenine and
thymine in a double-stranded DNA is ( 45 % ), the amount of guanine in this DNA will be
A . 22.5%
B . 27.5%
c. ( 45 % )
D. 55%
12
155If percentage of cytosine is ( 18 %, ) what will be the percentage of adenine?
A . 32%
B. 64%
c. 36%
D. 23%
12
156The width of B-DNA is
each turn of its helix has
nucleotides.
A. 34 A; 11
B. 20 ( dot{A} ; 12 )
c. ( 40 AA ; 8 )
D. ( 20 AA ; 10 )
12
157Write any four salient features of the Double helix structure of DNA.12
158The northern blot technique is used for the detection of
A. Protein
B. DNA
c. RNA
D. All of the above
12
159Match the components of lac operon of
E. coli with their functions. Choose the
answer with the correct combination of
alphabets of the two columns.
12
160B-DNA which is right-handed double helix contains ( _{-1-} ) base pairs per
turn of the helix and each turn is
long.
A. ( 10,3.4 AA )
B. 10,34 ,
c. ( 11,20 dot{A} )
D. 11,34 , ( dot{A} )
12
161In genetic coding, triplet codons make
possible 64 types of codons. If the genetic code was a doublet instead of a triplet codon, the number of types of codons possible would be
A. 64 types of codons
B. 4 types of codons
c. 24 types of codons
D. 16 types of codons
12
162In the processing of eukaryotic mRNA,
during protein synthesis, tailing
involves ………….. of RNA.
A. Addition of adenylate residues at ( 3^{prime} ) end
B. Addition of methyl guanosine triphosphate at ( 3^{prime} ) end
C. Addition of methyl guanosine triphosphate at ( 5^{prime} ) end
D. Removal of introns
12
163Influence of genes in controlling the activity of living organism is through
A. Photosynthesis
B. Protein synthesis
c. Vitamins
D. Hormones
12
164Which statement regarding translation
is out of order first?
A. Ribosomal subunits bind to mRNA
B. Ribosome comes to a stop codon on the mRNA
C. As a tRNA leaves the ribosome it passes its amino acid to the growing polypeptide
D. The messenger RNA codon binds to the tRNA anticodon
12
165The number of base substitution
possible in amino acid codons is
A. 26
B. 264
( c .535 )
D. 549
12
166Which of the following is a function of nucleosome?
A. It acts as a region of DNA transcription
B. It holds RNA in position
c. It helps in reducing the length of chromatin fibre
D. All of the above
12
167DNA differs from RNA in having
A. cytosine but no guanine
B. Thymine but no uracil
c. Uracil but no thymine
D. Thymine but no cytosine
12
168The lac operon model is
A. Inducible
B. Repressible
c. Both A and B
D. Degenerate
12
169Identify the correct and incorrect statements.
A. The four nucleotide bases are not
necessarily present in DNA in exact equal proportions.
B. The total amount of purines are equal to the total amount of pyrimidines.
C. DNA ligase enzyme act to hydrolyse or breakdown a polynucleotide chain into its component nucleotides.
D. Nuclease enzymes are capable of restoring an intact DNA duplex.
A. B is correct but A, C and D are wrong
B. A and B are wrong but C and D are correct
c. ( A, B ) and ( C ) are correct but D is wrong
D. A and B are correct but C and D are wrong
E. B, C and D are correct but A is wrong
12
170Assertion
Peptidyl transfer site is contributed by larger sub-unit of ribosome
Reason
The enzyme peptidyl transferase is contributed by both ( 23 S ) and 16 S ribosomal sub-units
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
c. Assertion is correct but Reason is incorrect
D. Both Assertion and Reason are incorrect
12
171During transcription, holoenzyme RNA
polymerase binds to a DNA sequence and the DNA assumes a saddle like
structure at that point. What is that
sequence called?
A. CAAT box
B. GGTT box
C. AAAT box
D. TATA box
12
172Describe the process of translation in
Protein synthesis
12
173The coding strand of DNA is
( mathbf{5}^{prime} boldsymbol{A} boldsymbol{A} boldsymbol{T} boldsymbol{T} boldsymbol{C} boldsymbol{A} boldsymbol{A} boldsymbol{T} boldsymbol{T} boldsymbol{A} boldsymbol{G} boldsymbol{G} mathbf{3}^{prime} )
What is the sequence of mRNA?
A . ( 3^{prime} )TTAAGTTTAATCC
c. ( 3^{prime} ) ААUUСААUU АGG5
D. ( 5^{prime} )TTAAGTTTAATCC
12
174What is the length of human DNA
containing ( 6.6 times 10^{9} ) bp nitrogen
bases?
( mathbf{A} cdot 22 n m )
B. ( 0.22 mathrm{mm} )
( mathbf{c} .2 .2 mathrm{m} )
D. 22m
12
175If molecular weight of a polypeptide is ( 15.3 k D a, ) what would be the minimum
number of nucleotides in the ( m R N A )
that codes for this polypeptide? Assume that molecule weight of each amino acid is 90 Da.
A .510
в. 663
c. 123
D. 17
12
176The process “translation” means
A. DNA synthesis
B. RNA synthesis
c. Protein synthesis
D. Ribosome assembly
12
177Differentiate between nucleoside and
nucleotide.
12
178Match the triplet codons mentioned in
list I with their amino acids mentioned
in listcolumn II and select the correct
option from the given codes.
12
179DNA strands are anti-parallel because
of
A. H-bonds
B. Phosphate diester bonds
c. Disulphide bonds
D. Peptide bonds
12
180During protein synthesis, amino acid gets attached to tRNA with the help of?
( A . ) mRNA
B. Aminoacyl synthetase
c. Ribosome
D. rRNA
12
181Watson and Crick model of DNA is a
A. ( B ) -form DNA with a spiral length of ( 34 AA ) and a diameter of ( 20 dot{A} )
B. ( A ) -form DNA with a spiral length of 15 and a diameter of ( 20 AA )
C. ( Z ) -form DNA with a spiral length of ( 34 AA ) and a diameter of ( 20 dot{A} )
D. ( B ) -form DNA with a spiral length of ( 28 dot{A} ) and a diameter of ( 14 dot{A} )
12
182The Southern blot technique is used for the detection of
A. DNA
B. RNAA
c. Protein
D. RNA and DNA
12
183“It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for genetic material” – This is written by
A. Meselson and Stahl
B. Archibold Garrod
c. severo ochoa
D. watson and Crick
12
184The process of formation of mRNA from
DNA is known as
A. Transformation
B. Translation
c. Transcription
D. Translocation
E. Relication
12
185By using only one of the two strands of DNA, mRNA is produced this process is called as
A. Transcription
B. Translation
c. Translocation
D. Replacement
12
186Wobble hypothesis for genetic code was
given by
A. Bernfield and Nirenberg
B. Crick
c. creighton
D. Hedges
12
187Choose the correct answer from the
alternatives given The lac operon is transcribed when
A. lactose is needed by the cell
B. lactose is available to the cell
c. lactose is unavailable to the cell
D. lactic acid is available to the cell
12
188The double helix model of Watson and
Crick is known as
A. C-DNA
B. B-DNA
c. z-DNA
D. D-DNA
12
189Find correct for both DNA and RNA
A . Ability to replicate
B. similar sugar
c. similar bases
D. Polymeric nucleotides
12
190What is transcription? What are the different parts of a DNA transcription
unit? What is their role in the process of transcription?
12
191Mention two functions of the AUG.12
192Calculate the number of nitrogen bases in E.coli, if the length of E.coli DNA is 1.36
( mathrm{mm} )
A ( cdot 4 times 10^{6} )
B. ( 8 times 10^{6} )
( c cdot 2 times 10^{6} )
D. ( 16 times 10^{6} )
12
193Choose the correct answer from the
alternatives given :
If the sequence of nitrogen bases of the coding strand of DNA in a transcription unit is: ( 5-A ) T ( G A A T G-3 ) the sequence of bases in its RNA
transcript would be
A. 5-AUGAAUG-3
B. 5-UACUUAC-3
c. 5 сАUUсАU 3
D. 5-GUAAGUA-3.
12
194What are the components of a
nucleotide?
12
19581. The one letter code for the amino acid tryptophan is
(a) G (b) V (c) W (d) H
(e) A
(Kerala PMT)
12
196Proteins have primary structures. If you are given a method to know which
amino acid is at either of two termini (ends) of a protein, can you connect this information to purity or homogeneity of a protein?
12
197The triplet UUU codes for
A. Leucine
B. Methionine
C. Phenyl alanine
D. Glycine
12
198Double helical structure of DNA was
proposed by
A. Kornberg
B. Nirenberg
c. watson and crick
D. Wilkins and Franklin
12
199134. Which of the following is correct about H-bonding in
DNA?
(a) A-T, G-C (b) A—G,T-G
(c) G-TA-C (d) A-AI-T
12
200Find the nucleotide sequence of the
MRNA which codes for the sequence of amino acids – ‘Met – Leu – Val – Arg – Ala’ and choose the correct option from
below:
A. AUG – GAU – GAA – UAU – UGU
B. AUG – GAU – GAA – CGU – GCC
c. AUG – CUA – GUG – UAU – UGU
D. AUG – CUA – GUG – CGU – GCC
12
201Choose the correct answer from the
alternatives given:

Identify the labels ( A, B, C ) and Din the
given structure of tRNA and select the
correct option.
A. A – Anticodon loop, B T ( Psi mathrm{C} ) loop, ( mathrm{C} ) – AA binding site, D DHU loop
B. A – AA binding site, B – TPsiC loop, C – Anticodon loop, D DHU loop
C. ( A-M ) binding site, ( B ) – DHU loop, ( C ) – Anticodon loop, ( D ) T ( Psi ) C loop
D. A – M binding site, B – DHU loop, C – TPsiC loop, D Anticodon loop

12
202mRNA that carries information for
complete polypeptide synthesis is
A. Muton
B. codon
c. operon
D. Reading frame
12
203In a typical bacterial operon, where is an
operator located to prevent
transcription?
A. Upstream of (before) the gene and the region of the promoter where RNA polymerase attaches.
B. Downstream of (after) the gene and the region of the promoter where RNA polymerase attaches.
C. At the location where the RNA polymerase attaches.
D. Between the gene and the region of the promoter where RNA polymerase attaches.
12
204Protein synthesis in an animal cell
occurs
A. Only on the ribosomes present in cytosol
B. On ribosomes present in cytoplasm as well as in mitochondria
c. only on ribosomes attached to the nuclear envelope and endoplasmic reticulum
D. On ribosomes present in the nucleolus as well as in cytoplasm
12
205Which enzyme plays important role in
transcription?
A. DNA dependent RNA polymerase
B. DNA dependent DNA polymerase
C. RNA dependent DNA polymerase
D. RNA dependent RNA polyrnerase
12
206In lac operon, structural gene ‘Z’ synthesizes
A. ( beta ) – galactosidase
B. Galactosidase permease
c. Galactosidase transacetylase
D. None of the above
12
207The following picture depicts the DNA
What is the structure of DNA ?
A. Spherical
B. Double Helix
C. Dumbell
D. Renal and longitudinal
12
208Explain the significance of ‘palindromic nucleotide sequence’ in the formation of recombinant DNA.12
209Suppose evolution on earth has
occurred in such a way that there are 96 amino acids instead of 20 DNA has 12
different types of bases and DNA synthesis occur in the same way as today.The minimum number of bases per DNA condon would be
A ( cdot 12 )
B. 8
( c cdot 2 )
D. 3
12
210Write the importance of DNA.12
211Which one of the following is the
complementary sequence for the DNA
with ( mathbf{5}^{prime} ) -CGTACTA-3′ ( ^{prime} )
A . ( 5^{prime} ) ‘-ТАGТАСG-3
B. 5′-ATCATGA-3
c. ( 5^{prime} ) -UTCUTGC-3′
D. 3′-GCATGAT-5’
12
212Given the fact that histone binds DNA, it
should be rich in.
A. Arginine, lysine
B. Cysteine, methionine
c. Glutamate, aspartate
D. Isoleucine, leucine
12
213Assertion
Non-sense codon are responsible for termination of peptide chain.
Reason
Non-sense codons are not recognised by
tRNA.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
c. Assertion is correct but Reason is incorrect
D. Both Assertion and Reason are incorrect
12
214In E.coli, the chain initiating amino acid
in protein synthesis is
A. N-formyl methionine
B. Methionine
c. Glycine
D. serine
12
215Protein synthesis in an animal cell
takes place
A. Only in the cytoplasm
B. In the cytoplasm as well as in mitochondria
C. In the nucleolus as well as in the cytoplasm
D. Only on ribose attached to nucleus
12
216In order to produce many copies of a protein fast, the cell uses
A. DNA replication
B. single-unit ribosomes for high speed translation
c. codon-anticodon reciprocal duplication
D. many RNA polymerase molecules to produce mRNA transcripts at the same time
12
217The bond formed between phosphate and pentose sugars of DNA is
A. Sulphide bond
B. Phosphodiester bond
c. Hydrogen bond
D. covalent bond
12
218The enzyme peptidyl transferase of prokaryotes resides in
A. 50 s ribosome
B. 30s ribosome
c. 40 s ribosome
D. 60 ribosome
12
219Technique for detecting and screening the nutritional mutants in Neurospora crassa was developed by
A. Beadle and Tatum
B. Bateson and Punnet
c. Luria Dulbecco
D. Knoll and Ruska
12
220The nucleotide sequence on antisense strand of DNA which is transcribed as
codon that specifies the amino acid serine is
A. TCA
B. AGUU
c. TAC
D. ccc
12
221In the Watson and Crick model of DNA,
the steps of the ladder are composed of
A . sugars
B. a purine and a pyrimidine
c. two purines
D. a sugar and a phosphate molecule
12
222Association of m-RNA with several
ribosomes is called
A. Polysome
B. Tranposons
c. Both A and B
D. None of the above
12
223Choose the correct answer from the
alternatives given :
In a DNA strand the nucleotides are
linked together by
A. Glycosidic bonds
B. Phosphodiester bonds
c. Peptide bonds
D. Hydrogen bonds
12
224Degenerated DNA after heating can be studied by comparing
A. A: T ratio
B. G: C ratio
c. sugar: phosphate
D. Number of nucleotides
12
225Which of the following is correct
regarding genetic code?
A. UUU is the initiation codon which also codes for phenylalanie.
B. There are 64 triplet codons and only 20 amino acids.
C. Three random nitrogen bases specify the placement of one amino acid.
D. UAA is the nonsense codon which also codes for
methionine.
12
226What would happen if a recombinant DNA is inserted within the coding
sequence of an enzyme, ( beta ) galactosidase?
A. This will result in the inactivation of the enzyme
B. The presence of chromogenic substrate will give blue coloured colonies
c. The recombinant colonies do not produce any colour
D. Both (1) and (3) are correct
12
227Describe the process of synthesis of fully functional ( m R N A ) in a eukaryotic
cell.
12
228Q Type your question
A DNA template plus primer with the structure
( 3 mathrm{P}-mathrm{TG} mathrm{C} ) GAATTAG ( mathrm{C} ) GACAT – PS
( 5 mathrm{P}-mathrm{ATCGGTACGACGCTTAAC} mathrm{OH} 3 )
(where ( P=a ) phosphate group) is placed in an in vitro DNA synthesis system containing ( M g^{2+}, ) an excess of the four
deoxyribonucleoside triphosphates, etc.
and a mutant form of E. Coli DNA
polymerase I that lacks ( 5 rightarrow 3 )
exonuclease activity. The ( 5 rightarrow 3 )
polymerase and. ( 3 rightarrow 5 ) exonuclease activities of this aberrant enzyme are
identical to those of normal E. Coli

DNA polymerase I. It simply has no ( 5 rightarrow ) 3 exonuclease activity. What will be the structure of the final product?
A. 3P-TGCGAATTAGCGACAT- P
5 P-ATCG GTAC GACG СТТААТСG СТGТА-ОН 3
в. 3 Р-т6СGААТтGGСGАСАТ- Р 5
5 Р-АтсG GтАСGАС ясттААС с с стятА-Он 3
c. 3нотяСЯААТтАGСGАСАТ Р 5
5-ATCG GTAC GACG CTTAATCG CTGTA – P 3
D. 3 Р тяСЯААТТАGСGАСАТ Р 5
5 Р -АСGСТТААТСЯСТЯТА-Онз

12
229TAIPMT (Mains)
ct when a phosphodiester
144. Find the hydrolysis product when a
bond of nucleotide breaks.
(a) 3-OH-deoxyribose-5-PO
(b) 5-OH-deoxyribose-3-PO
(c) 2-OH-deoxyribose-2-PO
(d) 4-OH-deoxyribose-2-PO
(All
12
230During translation, if the codon on ( m ) RNA is AUG, then
(i) What is the sequence of anticodon
present on corresponding t-RNA?
(ii) Name the amine acid carried by this
t-RNA.
12
231In a DNA molecule cytosine is ( 18 % ) Percentage of adenine would be
A . 32%
B. 64%
c. 36%
D. 18%
12
232In split genes, the coding sequences are called as
A. Introns
B. Operons
c. Exons
D. Cistrons
12
233mRNA directs the synthesis of proteins based on the sequence of
A. Exons
B. Introns
c. codons
D. Anticodons
12
234SD region in prokaryotic mRNA is a part of
A. TATA BOX
B. RBS (Ribosome Binding Site)
c. ASD region
D. Promoter
12
235Nucleosomes are not present in
A . Plant
B. Animal
C. Bacteria
D. Both A and B
12
236Consider the following sequence on mRNA, AUGGCAGUGCCA. Assuming that genetic code is overlap then how many number of codon may be present on this genetic code?
( A cdot 9 )
B. 10
( c cdot 8 )
D. 1
12
237Find the odd one out
A. Transcription
B. Transduction
c. Translocation
D. Mutation
12
23832. Genomic (DNA) studies in camel
have been completed recently by
the scientists of
(1) South Africa
(2) India
(3) China
(4) Pakistan
12
239The inducer for switching on the lac operon in bacteria is
A. Presence of lactos
B. Number of bacteria
c. Presence of structural genes in the bacteria
D. Presence of sucrose
E. Presence of RNA polymerase
12
240Jacob and Monad studied lactose
metabolism in E.Coli and proposed
operon concept. Operon concept applicable for : –
A. All prokaryotes
B. All prokaryotes and some eukaryotes
c. All prokaryotes and all eukaryotes
D. All prokaryotes and some protozoanes
12
241Identify the correct complementary base pairing among the following.
A. Adenine – Thymine and Guanine – Cytosine
B. Adenine – Guanine and Thymine – Cytosine
c. Adenine – cytosine and Thymine – Guanine
D. Guanine – Adenine and Cytosine – Adenine
12
242The enzyme which has polymerising
activity in ( 5^{prime} rightarrow 3^{prime} ) direction but
exonuclease activity in ( 3^{prime} rightarrow 5^{prime} )
direction only is :
A. RNA polymerase III
B. DNA polymerase II
c. DNA polymerase
D. All of these
12
243Choose the correct answer from the
alternatives given :
Amino acids which are specified by single codons are
A. Phenylalanine and arginine
B. Tryptophan and methionine
c. Valine and proline
D. Methionine and arginine
12
244Which one is odd process?
A. Translation
B. Transformation
c. Transduction
D. conjugation
12
245Write denaturing factors for proteins?12
246The peptide synthesis inside a cell takes place in
A. Ribosomes
B. Chloroplast
c. Mitochondria
D. chromoplast
12
247The triplet on coding strand of DNA is ATG. What would be the required anticodon on corresponding tRNA during translation?
A. UAA
B. UAG
c. UGA
D. UACC
12
248The nucleosomes are attached by
( mathbf{A} cdot ) SAT DNA
B. Linker DNA
c. Viral DNA
D. None of the above
12
249Which one of the following is not a structural part of a transcription unit in
DNA?
A. A promoter
B. The structural gene
c. The inducer
D. A terminator
12
250Which of the following is true of RNA, but not DNA?
A. RNA contains ribose
B. RNA contains adenine, guanine, cytosine and thymine
c. RNA is usually double stranded
D. RNA is produced using complementary base pairing
12
251The one aspect, which is not a salient feature of genetic code, is its being
A. Ambiguous
B. Universal
c. specific
D. Degenerate
12
252What is the function of non-histone
protein?
12
253If the length of DNA strand is ( 68 A^{circ} ) then, what will be the number of nucleotides
present in DNA molecule
A . 20
B. 40
( c cdot 60 )
D. 80
12
254What will be the length of eukaryotic
DNA segment having 10 pairs of nucleotides?
12
255toppr LOGIN JOIN NOW
( widehat{n} )
Q Type your question
( – )
( A cdot A-p, B-q, C-r, D-t, E-s )
B. ( A-r, B-p, C-t, D-s, E-q )
( mathbf{C} )
1 ( alpha ) – ( r, C-s, D-p, E-t )
3- ( t, C-q, D-r, E-p )
( D )
-1
( E cdot A-t, B-s, C-p, D-q, E- )
12
256What will be the correct gene expression
pathway?
A. Gene-mRNA- transcription-translation-protein
B. Transcription-Gene-translation-mRNA-protein
C. Gene-transcription-mRNA-translation-protein
D. Gene-translation-mRNA-transcription-protein
12
257Guanine pairs with
A. Adenine
B. Cytosine
c. Thymine
D. None of the above
12
258In a DNA molecule, the phosphate group is attached to ( _{–} ) carbon of the sugar
residue of its own nucleotide
and ( _{-1-1} ) carbon of the sugar
residue of the next nucleotide
by bonds.
A. 5 ‘, 3 ‘, phosphodiester
B. 5′, 3’, glycosidic
c. 3 ‘, 5′, phosphodiester
D. 3′, 5’, glycosidic
12
259What properties of the bacteriophages made them ideal material for solving
the controversy regarding the genetic material to be protein or DNA ?
12
260Which RNA carries information from
DNA in protein synthesis?
A. snRNA
B. tRNA
c. rRNA
D. mRNA
12
261Double helix model of DNA which was
proposed by Watson and Crick was of
A. C-DNA
B. B-DNA
c. D-DNA
D. z-DNA
12
262(a)Name the chemical that cements
animal cells.
(b)Name two contractile proteins.
(c)What is the difference between RNA
and DNA in their nitrogen bases.
12
263Portion of gene, which is transcribed but not translated is?
( A ). Exon
B. Intron
c. cistron
D. codon
12
264The process of the formation of RNA
from DNA is
A. Transduction
B. Transcription
c. Transversion
D. Transition
12
265Collect 5 examples of palindromic sequence by consulting your teacher. Better try to create a palindromic sequence by following base-pair rules.12
266Name the parts ( a, b ) and ( c )12
267Codon degeneracy means that
A. Several of the amino acids are coded by more than one codon
B. One codon can code for many amino acids
C. One amino acid can be coded by only one codon.
D. The codons are triplet nucleotide sequences.
12
268What is a codon? How many codons serve as stop (non-sense) codons and
how many as initiating codons?
12
269Nucleosome contains
( mathbf{A} cdot H_{2} A, H_{2} B, H_{3}, H_{4} )
( mathbf{B} cdot H_{3}, H_{4} )
( mathbf{c} cdot H_{2} A, H_{2} B, H_{3} )
D. ( H_{1}, H_{2} A, H_{2} B, H_{3} )
12
270Rosalind Franklin produced an X-ray image that helped Watson and Crick determine the width of a DNA molecule.
What did this information help them
realize?
A. Bonding between two purines would be consistent witt the diameter of the DNA helix
B. Chargaffs Rule did not apply to the DNA molecule
c. Bonding between a purine and pyrimidine would be consistent with this width of a DNA helix since each rung has a three-ring molecular dimension.
D. Adenine must bond with cytosine, and guanine must bond with thymine on each rung of the DNA ladder to accommodate for proper diameter of the double helix
12
271Structures called beads on string are
A. Nucleosomes
B. Base pairs
c. Genes
D. Nucleotides
12
272Write the important features of genetic
code.
12
273Enlist the type of non-genetic RNA. What
is a gene responsible for expression of a
trait called?
12
274Phosphorus is present in
A. Protein
B. DNA
( c . ) RNA
D. Both DNA and RNA
12
275Assertion
A change in nitrogen base at the third
position of a codon causes change in
the expression of the codon.
Reason
A codon is mostly read by all the three nitrogen bases.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
c. Assertion is correct but Reason is incorrect
D. Both Assertion and Reason are incorrect
12
276Melting temperature for double stranded molecules are converted into
single stranded molecules. Which one
of the following DNA will have the highest melting temperature?
A. DNA with ( 15 % ) guanine
B. DNA with 30% cytosine
C. DNA with ( 40 % ) Thymine
D. DNa with ( 50 % ) adenine
12
277A codon is made up of
A. single nucleotide
B. Two nucleotides
C. Three nucleotides
D. Four nucleotides
12
278DNA differs from RNA in having
A. Uracil
B. Thymine
C. Adenine
D. Guanine
12
279Degeneration of a genetic code is attributed to the
A. First member of a codon
B. Second member of a codon
c. Entire codon
D. Third member of a codon
12
280Sequencing of genomic DNA is included under
A. Structural genomics
B. Functional genomics
c. Proteomics
D. Transgenesis
12
281Read carefully the sequence of codons
in the mRNA unit and answer the
questions.
(a) What change is needed in the first codon to start the translation process?
(b) If translation starts by that change, till which codon it can continuous?
Why?
12
282According to Watson-Crick model hydrogen bonding in a double-stranded
DNA occurs between.
A. Adenine and guanine
B. Adenine and thymine.
c. cytosine and adenine.
D. Guanine and thymine.
12
283In the double helix model of DNA as
proposed by Watson and Crick, each base pair is how far from the next base
pair?
( A cdot 0.034 mathrm{nm} )
B. 0.34 nm
( c .3 .4 mathrm{nm} )
D. 34 nm
12
284DNA strands
A. Have quaternary structure like protein
B. Are bonded by disulphide bonds
C. Have same polarity
D. Are antiparallel
12
285During the molecular functioning of genes, which process converts RNA into protein?
A. Trancription
B. Translation
c. Transfection
D. Transfusion
12
286Template theory suggests
A. Amino acids have to be activated
B. Acylation
C. Combination of amino acid with tRNA first
D. All of the above
12
287Who discovered genetic code?
A. Nirenberg
B. Khorana
c. Ochoa
D. Crick
12
288Fill the columns and complete the given
table. Give explanation for your answer
12
289Define translocation.12
290Which of the following is a nucleoside?
A. Adenosine
B. Adenine
c. Deoxyribose
D. Adenylic acid
12
291Correct sequence for Alanine code is
A . GCU, GCC, GCA
B. GAU, GAC, GAA
c. AGU, AGC, AGA
D. GUU, GUC, GUA
12
292Genetic code consists of
A. 4 codons, each with two nucleotides
B. 16 codons, each with four nucleotides
C. 64 codons, each with two nucleotides
D. 64 codons, each with three nucleotides
12
293Polysomes lack
A. Proteins
B. mRNA
c. DNA
D. tRNA and rRNA
12
294In DNA replication, the primer is
A. A small deoxyribonucleotide polymer.
B. A small ribonucleotide polymer.
C . Helix destabilizing protein.
D. Enzyme taking part in joining nucleotides of new strand.
12
295Which of the following is important for transcription?
A. CAAT box
B. Promoter
c. RNA polymerase
D. All of the above
12
296Which of the following statements about nucleosome is true?
A. It consists of only DNA.
B. It is a nucleus-like structure found in prokaryotes
c. It consists of DNA and proteins
D. It consists of only histone proteins
12
297Which of the following is not correct about translation?
A. It starts with AUG.
B. Stopped at termination codon
c. Based on operon model.
D. Occurs in nucleus
12
298Which one of the following process occurs inside the nucleus during protein synthesis in a eukaryotic cells?
A. Processing of hnRNA
B. Activation of amino acids
c. Translation
D. Formation of polypeptide chain
12
299Which codon does not have tRNA?
A. Start codon
B. Stop codon
c. Aua
D. GGG
E. UUU
12
300Variegated coloration of leaves, first studied by K.Correns in 1909 is inherited only from the female parent. The genes coding for this trait are located in
A . ER
B. Nucleus
c. Plastids
D. Plasma membrane
12
301Which of the following is a transcription factor produced by a regulatory gene?
A. A promoter
B. An operon
c. A cofactor
D. A repressor
12
302Assertion
Transcription unit is often monocistronic in eukaryotes and polycistronic in prokaryotes.
Reason
Exons do not appear in mature RNA,
introns appear in mature RNA.
A. Assertion and Reason are true, Reason is correct explanation of Assertion.
B. Assertion and Reason are true, Reason is not the correct explanation of Assertion
C. Assertion is true, Reason is false.
D. Assertion is false, Reason is true.
12
303When a single anticodon can recognize more than one codon of mRNA it is called as
A. Template hypothesis
B. Degeneracy
c. Gene flow hypothesis
D. collinearity hypothesis
12
304The following diagram shows a protein coding DNA and specifies the positions of its translational start and stop
signals
( 5^{prime} . . . . . . . . mathrm{G} mathrm{AT} ldots . . . . . . . )
Which of the following statements with
regard to template strand for the RNA
polymerase and the C-terminus of the
resulting protein is true?
A. Upper is template strand, carboxy terminus of protein to right.
B. Upper is template strand, carboxy terminus of protein to left
C. Lower is temperate stand, carboxy terminus of protein to right.
D. Lower is template strand, carboxy terminus of protein to left.
E. Either strand could be a template on basis of this information
12
305How many nucleotides in messenger RNA’s sequence makes a codon for an amino acid?
A. Three
B. Four
c. one
D. Two
12
306What is nucleosome? Draw diagram of double stranded polynucleotide chain of DNA and explain its structure.12
307What is transformation?12
308Choose the correct answers from the
alternatives given. What is the function of DNA ligase in recombinant technology?
A. Cut DNA into many fragments
B. Carry DNA into a new cell
c. Link together newly joined fragments of DNA
D. Separate fragments of DNA by their length and electrical charges
12
309Termination of chain growth in protein synthesis is brought about by the
codons
A. UAA, UAG and UGA
в. UCG, АСС аnd GсG
c. UUG, UAG and UGA
12
310DNA is associated with basic protein
A. Albumin
B. Non-histone
c. Histone
D. Both A and C
12
311If DNA was made of 6 nucleotides
instead of ( 4, ) what are the total number of triplet codons possible?
A .24
B . 18
( c .64 )
D. 216
12
312Which of the following is not produced by E.Coli in the lactose operon?
A. ( beta ) galactosidase
B. Galactoside transacetylase
c. Lactose dehydrogenase
D. Galactoside permease
12
313What are introns?12
314Describe the experiment performed by
Griffith. What conclusions did he infer
from his observations?
12
315Wobble hypothesis was proposed by
A. Holley
B. Nirenberg
c. Khorana
D. Crick
12
316Production of a human protein in
bacteria by genetic engineering is possible because
A. Bacterial cell can carry out the RNA splicing reactions.
B. The mechanism of gene regulation is identical in humans and bacteria
c. The human chromosome can replicate in bacterial cell.
D. The genetic code is universal
12
317In genetics, a reference is made to an abbreviated expression AUG. Write any three points of scientific information embodied in this
combination of three letters.
12
31836. Transcription means the synthe
sis of
(1) Lipids (2) Protein
(3) DNA (4) RNA
12
319Which among the equations of the nitrogenous base content in the DNA is
not true?
A ( cdot A+G=T+C )
B. ( A+T=G+C )
( c cdot G=c )
12
320Explain the dual function of AUG codon. Give the sequence of bases it is transcribed from and its anticodon.12
321Which of the following inhibits protein synthesis by binding to 50S ribosome?
A. Tetracycline
B. Streptomycin
c. Erythromycin
D. Penicillin
12
322DNA found in the nucleus is wrapped
around a simple protein which is basic in nature. This protein is also thought to regulate DNA functioning find some way. Name this protein.
A. Collagen
B. Renin
c. Pepsin
D. Histones
12
323Choose the correct order of the steps
involved in protein synthesis and
modification that takes place in several different locations throughout the cell.
I. Ribosome
II. Nucleus
III. Golgi apparatus
IV. Endoplasmic reticulum
A . ।, ॥, III and IV
B. ॥,।, IV and III
c. ॥ा, ॥, Iv and ।
D. ॥, I, III and IV
E . IV, III, II and I
12
324Which of the following act as a substrate for an enzyme that charges
tRNA molecules?
I. Amino acid
I. ATP
III. tRNA
IV. snRNA
A. I only
B. II only
c. ॥ा only
D. I, II, and III
E . ।, ॥, ॥ा, and IV
12
325Examine the data showing the percent identity of the GAPDH gene and protein sequences between humans and the
three species shown below.
Species G
lo ( begin{array}{ll}text { Gene } & text { Protein } \ text { ldentity } & text { ldentity }end{array} )
99.6% ( quad 100 % ) Chimpanzee
Fruit Fly 72.4% 76.7%
Roundworm ( 68.2 % ) 74.3%
Provide a possible reason for why the percent identity between gene sequences is lower than the percent identity of protein sequences.
A. Multiple codons code for the same amino acid
B. Introns are likely to have different sequences.
c. Differences in DNA sequences are edited when the mRNA is transcribed
D. Amino acids cannot be substituted without consequence
12
326A codon in mRNA has
A. 3 bases
B. 2 bases
c. 1 base
D. Number of bases vary
12
327Assertion
Histones are basic proteins of major importance in packaging of eukaryotic DNA. DNA and histones comprise chromatin forming the bulk of
eukaryotic chromosome.
Reason
Histones are of five major types: ( mathrm{H} 1 ) H2A, H2B, H3 and H4.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion.
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
C. Assertion is correct but Reason is incorrect.
D. Both Assertion and Reason are incorrect.
12
328State whether the following statements
are true or false.
All of the molecules available for
biosynthesis constitute the metabolic pool
A. True
B. False
12
329Differentiate between translation and
translocation.
12
330In the lac operon, the structural genes
are switched off when repressor binds
to the
A. Operator
B. Promoter
c. Regulator
D. Inducer
E. Allolactose
12
331Out of 64 codons only 61 codes for the 20
different amino acids. This character of genetic code is called as
A. Degeneracy
B. Non ambiguous nature
c. Redundancy
D. Overlapping
12
332The chemical differences between DNA
and RNA are
A. DNA has deoxyribose sugar and RNA has ribose sugar
B. DNA is double stranded and RNA is single stranded
C. Nitrogenous bases are only present in DNA.
D. Both A and B
12
333In which of the following would you expect to find the most highly
conserved sequences of nucleic acids?
A. Structurally critical regions of a polypeptide such as an active site region
B. The intron regions of pre-mRNA sequences
C. Ribosomal RNA sequences
D. Bacterial genes conferring antibiotic resistance
12
334Describe Watson and Crick’s model of
DNA.
12
335How do ( m-R N A, t-R N A ) and ribosomes
help in the process of translation?
12
336An operon unit consist of
A. Regulator, operator and recessive gene
B. Regulator, structural and operator gene
C. Regulator, structural, operator and promoter gene
D. Regulator, structural and promoter gene
12
337Read the statements 1 and 2 . Choose the
correct option:
Statement 1: RNAi take place in all prokaryotic and eukaryotic organisms as a method ofcellular defence.

Statement 2: RNA interference is a pre-
translational process.
A. Both statements are correct
B. Statement I correct, statement 2 incorrect
c. Both statements are incorrect
D. Statement-1 incorrect, statement 2 correct.

12
338Which one of the following is a base analogue?
A. Nitrous acid
B. Colchicine
c. 5 – bromouracil
D. Caffeine
12
339Elongation of peptide chain involves all
except
( A . ) mRNA
B. GTP and peptidyl tranferase
c. Tu, Ts and G factors
D. Formyl met-tRNA
12
340( ln ) a 125 amino acid sequence, if ( 25^{t h} ) amino acid is mutated to UAA, then
A. A polypeptide of 124 amino acids is formed.
B. A polypeptide of 25 amino acids is formed
c. A polypeptide of 24 amino acids is formed.
D. Any of the above can be possible.
12
341List the criteria a molecule that can act
as genetic material must fulfill. Which one of the criteria are best fulfilled by
DNA or by RNA thus making one of them a better genetic material than the other?
12
342Due to deficiency of phosphorus.
A. The rate of protein synthesis is increased
B. The rate of protein synthesis is decreased
C. There is no effect on the rate of protein synthesis
D. The rate of protein synthesis initially declines but increases later on
12
343Distinguish between DNA and RNA.12
344A gene encoding for polypeptide of 50 amino acids get mutated at 25 codon; UAU becoming UAA. The result would be
A. Polypeptide of 24 amino acid
B. Two polypeptides one with 24 amino acids and second with 25 amino acids
c. A polypeptide with 49 amino acid
D. A polypeptide of 25 amino acids
12
345132. What type of sugar molecule is present in DNA?
(a) D-3-Deoxyribose (b) D-Ribose
(C) D-2-Deoxyribose (d) D-Glucopyranose
AUT
12
346Ribosome in eukaryotes involves in
A. Transformation
B. Translation
c. Transcription
D. Translocation
E. Replication
12
347The anticodon found on the t-RNA for
trytophan amino acid is
A. ucc
B. cuu
c. АСС
D. UGG
12
348The tRNA anticodon 3-UAC-5 will pair
with the mRNA codon
A. 5-AUU-3
B. 5-UAC-3
c. 5-AUG-3
D. 3-GUA-5
12
349Choose the incorrect statement
regarding DNA structure.
A. Base stacking destabilise DNA double helical structure.
B. Each chain in DNA constitute sugar-phosphate backbone
C. Two chains are coiled in right handed fashion
D. The pitch of the helix has roughly 10 bp.
12
350Which one of the following group of
codons is called as degenerate codons?
A. UAA, UAG and UGA
B. GUA, GUG, GCA and GCG
C . UUC, UUG, CCU, CAA and CUG
D. UUA and UUG, CUU, CUC and CUG
E . AAC, AAG, GAC and CGG
12
351The enzyme involved in transcription is
A. RNA polymerase
B. DNA polymerase I
c. DNA polymerase II
12
352Select the correct option regarding genetic code of Glycine.
A. GUU, GUC, GUA
B. GAU, GAC, GAA
c. GGU, GGА, яGС
D. GGU, GGA, GCU
12
353Give reasons Genetic code is universal.12
354Identify the disadvantages of RNA over DNA as a genetic material and explain ¡t.12
355Which of the following is a sulphur containing amino acid
A. Alanine
B. Glycine
c. Methionine
D. valine
12
356All of the following are involved in prokaryote protein synthesis except
A. Introns are removed from the mRNA transcript
B. RNA polymerase copies DNA into RNA nucleotides to produce mRNA
C. Translation occurs simultaneously with transcription.
D. Transcription and translation occur in the cytoplasm.
E. All of the above events occur in prokaryote protein synthesis
12
357Which of the following are associated with a consensus sequence and a signal sequence?
A. Translation, hnRNAs
B. DNA, translation
c. Transcription, a snurp
D. hnRNA, a snurp
E. Spliceosomes, translation
12
358What is the common point of similarity between DNA and RNA?
A. Both are double stranded
B. Both have identical sugar molecules
c. Both have identical pyrimidine bases
D. Both are polymers of nucleotides
12
359Draw the schematic/diagrammatic presentation of the lac operon.12
360The mechanism of removing introns followed by joining of the exons in a defined order during transcription is called
A. Splicing
B. Tailing
c. Transformation
D. Capping
12
361Nitrogenous base present in DNA are
(a) Thymine
(b) Cytosine
(c) Adenine
(d) Guanine
( A cdot a, b, c )
B. a, c, d
( c cdot b, c, d )
D. all
12
362Which property of DNA double helix led Watson and Crick to hypothesise semiconservative mode of DNA replication? Explain.12
363Which of the following anticodon sequence will bind to the transcribed codon ( 5^{prime}-A C T-3^{prime} ? )
A . 3′-ACU-5′
B. 3′-TGA-5′
c. 3′-UGA-5′
D. 5′-UGA-3′
E. None of the above
12
364In animal tissue culture which of the
following radioactive nucleotide is used to measure RNA synthesis?
A. Adenine
B. Cytosine
c. Guanine
D. Thymine
E. Uracil
12
365Assertion
Replication and transcription occur in the nucleus but translation takes place
in the cytoplasm.
Reason
mRNA is transferred from the nucleus
into cytoplasm where ribsomes and amino acids are available for protein
synthesis.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
C. Assertion is correct but Reason is incorrect
D. Both Assertion and Reason are incorrect
12
366E. coli cells with a mutated Z gene of the
lac operon cannot grow in medium containing only lactose as the source of energy because
A. In the presence of glucose, E. coli cells do not utilize lactose
B. They cannot transport lactose from the medium into the cell.
c. The lac operon is constitutively active in these cells.
D. They cannot synthesize functional ( beta ) -galactosidase.
12
367Length of one loop of B DNA is
( A .3 .4 mathrm{nm} )
B. 0.34 nm
( c cdot 20 mathrm{nm} )
D. ( 10 mathrm{nm} )
12
368Consider these sentences regarding the structure and nature of DNA.
I. DNA has two pyrimidine bases that contain single ring structure.
II. In DNA, composition of bases should be ( frac{boldsymbol{A}+boldsymbol{T}}{boldsymbol{G}+boldsymbol{C}}=mathbf{1} )
III. Each base pair of DNA is ( 3.4 A ) apart from other base pairs.
IV. The nucleosome model DNA
packaging was proposed by Kornberg and Thomas.

Choose the correct statements from the
given options.
A. I and III
B. I, II and III
c. ॥, ॥ा and IV
D. I, III and IV

12
369Group the following as nitrogenous
bases and nucleosides:
Adenine, Cytidine, Thymine, Guanosine, Uracil and Cytosine.
12
370Transcription unit
A. starts with TATA box
B. starts-with pallendrous regions and ends with rho factor
C. starts with promoter region and ends in terminator region
D. starts with CAAT region
12
371What would be the molar concentration
of human DNA in a human cell? Consult
your teacher.
12
372Which of the following is required as inducer(s) for the expression of Lac operon?
A. Glucose
B. Galactose
c. Lactose
D. Lactose and galactose
12
373Which one of the following is a stop codon?
A . UAGGGGGG
B. UAC
c. AUG
D. UcA
12
374Diagrammatically represent the experimental steps in cloning and expressing a human gene (say the gene for growth hormone) in a bacteria like ( E )
coli?
12
375Which of the following statement is true
about RNA?
A. It contains adenine paired to thymine
B. One of the bases from DNA is replaced by uracil
C. It contains the sugar deoxyribose
D. Its nucleotides contain twice as many phosphate groups as DNAs nucleotides
12
376In a dsDNA number of phosphodiester
bonds are 3250 , then find the number of
base pairs.
A. 1625
B. 1626
c. 3252
D. 3250
12
377UAA, UAG and UGA are
A. Non overlapping codons
B. Non sense codons
C. Degenerate codons
D. Chain initiator codons
12
378Choose the correct answers from the
alternatives given:
Transcription is the transfer of genetic code from a DNA molecule to a
A. RNA molecule
B. Second DNA molecule
c. Ribosomal subunit
D. Sequence of amino acids in a protein molecule
12
379Which of the following biologists has been dubbed as the architect of molecular biology?
A. Francis Crick
B. Frederick Sanger
c. Jacques Lucien Monod
D. James Watson
12
380Sequence of amino acid in polypeptide chain is determined by
( A cdot r R N A )
B. sn RNA
c. n RNA
D. m RNA
12
381Choose the correct answer from the
alternatives given :
An organism uses 20 amino acids while its DNA is made up of 6 types of nitrogenous bases. What would be the minimum size of a codon?
( A cdot 6 )
B. 4
( c cdot 3 )
D. 2
12
382Which of the following organelle is responsible for differentiation?
A. Nucleus
B. Mitochondria
c. Ribosomes
D. Centrioles
12
383Chloramphenicol prevents protein synthesis over
A. Prokaryotic ribosomes
B. Organelle ribosomes
c. Both A and B
D. 80 S ribosomes
12
384The template for protein synthesis is
A. DNA
B. mRNA
c. rRNA
D. tRNA
12
385A living cell is characterized by the presence of several cellular structures
and molecular processes. The correct statement regarding living cells is
A. The nucleus is a characteristic feature of all living cells
B. An mRNA sequence is never completely represented in its translated product
c. Anticodons are located on the rRNA
D. splicing of introns in prokaryotes occurs in the cytoplasm
12
386What is the width of DNA molecule?
A ( cdot 15 mathrm{A}^{circ} )
B. 20 A ( ^{text {о }} )
c. ( 25 mathrm{A}^{circ} )
D. 34 A
12
387Diameter of DNA double helix is
( A cdot 34 A^{0} )
B . 20 ( A^{0} )
c. ( 3.4 A^{circ} )
D. 340 ( A^{circ} )
12
388Which is the principal site for the development of ribosomal RNAs?12
389Assertion
A monocistronic mRNA can
produce several types of polypeptide
chains.
Reason
The terminator codon is present on
the mRNA.
A. Both Assertion and Reason are correct and Reason is the correct explanation for Assertion
B. Both Assertion and Reason are correct but Reason is not the correct explanation for Assertion
c. Assertion is incorrect but Reason is correct
D. Both Assertion and Reason are incorrect
12
390How did Hershey and Chase prove that DNA is the genetic material?12
391Choose the correct answer from the
alternatives given :

If Meselson and Stahls experiment is continued for four generations in bacteria, the ratio of ( N^{15}-N^{15}, N^{14}- )
( N^{15}, N^{14}-N^{14} ) containing DNA in the fourth generation would be
A . 1:1:10
B. 1:4:0
c. 0: 1: 3
D. 0:1:7

12
392The first amino acid in any polypeptide chain of prokaryote is always
A. Formylated methionine
B. Formylated arginine
c. Lysine
D. Methionine
12
393Question 24. Write the important structural and functional differences
between DNA and RNA.
12
394If there are 120 adenine molecules in a
B-DNA double helical structure showing 20 coils, what is the number of
pyrimidine nucleotides forming three hydrogen bonds in it?
( A cdot 80 )
B. 100
( c cdot 120 )
D. 140
12
395Differentiate (three) between DNA and
RNA.
12
396The structure of DNA is
A. Linear
B. Double helix
C. single helix
D. Triple helix
12
397A mRNA coding for a secretory protein, when translated using free ribosome under in vitro conditions, resulted in a
( 40 k D a ) protein. The same mRNA when translated using the rough endoplasmic reticulum resulted in a
( 36 k D a ) protein. The difference in the
molecular weight of the two
polypeptides is due to the loss of a
A ( .2 k D a ) peptide from ( N ) -terminus and a ( 2 k D a ) peptide from the C-terminus
B. ( 1 k D a ) peptide from ( N ) -terminus and a ( 3 k D a ) peptide from the C-terminus
C. ( 4 k D a ) peptide from the N-terminus
D. ( 4 k D a ) peptide from the C-terminus
12
398DNA differs from RNA in
A. Nature of sugar alone
B. Nature of purines alone
c. Nature of sugar and pyrimidines
D. All the above
12
399Which of the following is characterized by the tightly coiled, condensed form of DNA that is not transcribed?
A. Promoter
B. Enhancer
c. operator
D. Euchromatin
E. Heterochromatin
12
400Which one of the following is wrongly
matched?
A. Transcription – Writing information from DNA to t-RNA
B. Translation – Using information in mRNA to make protein
C. Repressor protein – Binds to a operator to stop enzyme synthesis
D. Operon – Structural genes, Operator and Promoter
12
401What are the differences between DNA
and RNA?
12
402Purine base of DNA molecule has
A. A and
B. c and T
c. A and a
D. None of the above
12
403What do you understand by the antiparallel arrangement of DNA strands?12
404Transfer of information from molecule of
DNA to mRNA is called as
A. Transcription
B. Translation
c. Replication
D. None of the above
12
405Formation of mRNA from DNA is called
as
A. Translation
B. Transcription
c. Transformation
D. Transduction
12
406Find the sequence of binding of the
following amino acyl-tRNA complexes during translation of an mRNA transcribed by a DNA segment having the base sequence 3’TACATGGGTCCG5′. Choose the answer showing the correct order of alphabets.
A. P, Q, s,
в. Q, Р, s,
c. Р, ( Q, ) R,
D. Q, P, R,
12
407The monomers of a polyribonucleotide
are
A. Deoxyribonucleotides
B. Ribonucleosides
c. Polypeptides
D. Ribonucleotides
12
408With the help of a neat and labeled diagram describe Waston and Crick’s
model of DNA.
12
409Peptidyl transferase plays an important role during protein synthesis. What is true about this enzyme?
A. It is proteinaceous
B. It is RNA as catalyst
c. It helps in peptide bond formation
D. Both B and C
12
410What does lac refer to in the lac operon?
A . Lactase
B . 1,00,000
c. Lac insect
D. Lactose
12
411Balbiani rings are sites of which of the following?
A. DNA replication
B. RNA and protein synthesis
c. synthesis of lipids
D. Synthesis of polysaccharides
12
412Which one of the following triplet codes, is correctly matched with its specificity for an amino acid in protein synthesis or as ‘start’ or ‘stop’ codon?
A . UCG – Start
B. UUU – Stop
c. UGU – Leucine
D. UAC – tyrosine
12
413Choose the correct answers from the
alternatives given :
Transcription involves
A. synthesizing the protein on the ribosome
B. transferring information contained in the DNA to mRNA
c. joining amino acids by peptide bonds
D. transferring information from the mRNA to tRNA
12
414Question 22. What is the difference between a nucleoside and a
nucleotide?
12
415Briefly describe the following:
(a) Transcription
(b) Polymorphism
(c) Translation
(d) Bioinformatics
12
416(a) In an experiment Griffith introduced heat-killed S-strain bacteria
Streptococcus into a mouse along with live R-strain bacteria. The mouse died
but the scientist recovered living ( mathrm{S} ) strain bacteria from the dead mouse
Explain the conclusion Griffith arrived at after the experiment.
(b) Explain MacLeod, McCarty and Averys work that followed Griffith’s experiment. State the conclusion they arrived at.
12
417Explain aminoacylation of tRNA.12
418Which conserved motif occur in
Escherichia coli genes?
A. TATA box
B. CAAT box
c. Pribnow box
D. None of the above
12
419If the sequence if the nitrogenous bases on template strand is ATCTGGCGT, what
would be the sequence of mRNA transcribed from it?
A . AUCACCGCU
в. UUcUGGCGU
c. UAGACCGCA
D. AUGUccGCU
12
420Protein synthesis in an animal cell
occurs
A. On ribosomes present in cytoplasm, ER as well as in mitochondria
B. On ribosomes present in the nucleolus as well as in cytoplasm.
c. only on ribosomes attached to the nuclear envelope and endoplasmic reticulum.
D. only on the ribosomes present in cytosol
12
421Ribozyme is
A. An enzyme, which helps in protein synthesis
B. An enzyme, which joins thymine to adenine
C. An enzyme, which helps in degeneracy
D. Exceptional to eukaryotes
12
422In nucleoside, the nitrogen base is attached to the first carbon of sugar by bond.
A. Glycosidic
B. Hydrogen
c. Phosphodiester
D. Phosphate
12
423For every single amino acid incorporated in peptide chain
ATP and GTP molecules are
used.
A ( cdot 1,4 )
B. 1,6
( c cdot 1,2 )
D. 1, 3
12
424First strand of cDNA can be synthesized
by
A. Transaminase
B. DNA ligase
c. RNA dependent DNA polymerase
D. DNA dependent DNA polymerase
12
425Instead of ( 3, ) if it was 2 bases code for
an amino acid, the degeneracy of codons coding for the same amino acid
would have
A. Increased
B. Decreased
c. Remained the same
D. Been uncertair
12
426Which conserved motifs are found in
E.coli genes?
A. TATA box
B. CAAT box
c. Pribnow box
D. All of the above
12
427Degeneracy of the genetic code denotes the existence of
A. Multiple codons for a single amino acid
B. Wobble hypothesis
c. Base triplets that do not code for amino acids
D. All of the above
12
428What is the function of a non-sense
codon?
A. To release polypeptide chain from tRNA.
B. To form an unspecified amino acid.
C. To terminate the message of a gene controlled protein synthesis.
D. To convert a sense DNA into non sense DNA.
12
429After a mutation at a genetic locus, the
character of an organism changes due to the change in which one of the following?
A. Protein synthesis pattern
B. RNA transcription pattern
c. Protein structure
D. DNA replication
12
430The environmental factor that
influences the elongation of polypeptide chain is
A. Light
B. Oxygen
c. Humidity
D. Temperature
12
431Select the wrong statement
A. Presence of chromogenic substrate gives blue colour colonies if the plasmid in the bacteria does not have an insert
B. Retroviruses in animals have the ability to transform normal cells into cancerous cellsın microinjection, cells are bombarded with high velocity microparticles of gold or tungsten coated with DNA
C. since DNA is a hydrophilic molecule it cannot pass through cell membranes
D. DNA is a negatively charged molecule
12
432Ribosomes are the site for
A. DNA replication
B. Transcription
c. Translation
D. Translocation
E . Repression
12
433Which site of the RNA pairs through hydrogen boding with the triplet codes on mRNA?
A. codon
B. ( 5^{prime} ) end of tRNA
c. ( 3^{text {‘ end of tRNA }} )
D. Anticodon
E. Amino acid acceptor end
12
434The codon for anticodon 3′-UUUA-5′ is
A. ( 3^{text {‘-AAU-S }} )
B. 5′-UAAA-3′
c. 5′-AAAU-3
D. 3′-UAAU-5’
12
435In a double-stranded DNA, the sequence
of base pairs in one strand is

AGCTAAGC. What is the complementary sequence on the other strand?
A. TCGATTCG
B. UCGAUUCG
c. АGСТААGС
D. сАUтАUСG

12
436Which of the following is initiation codon?
A . AUGGGGGGGGG ( . ) GGGGG
B. AUU
c. UAG
D. uvu
12
437138. Adenosine is an example of
(a) purine base (b) nucleoside
(c) nucleotide
(d) pyrimidine base.
12
438Explain the steps involved in translation12
439Out of the following statements, which
one is true?
A. DNA is single stranded, RNA is double stranded
B. There is only one type of RNA, whereas there are many types of DNA.
c. DNA synthesizes RNA, but RNA generally cannot synthesize DNA.
D. DNA bases are adenine, guanine, cytosine, uracil and RNA has adenine, guanine, cytosine, thymine
12
440Double helix model of DNA was
proposed by
A. Nirenberg
B. Komberg
c. Holley and Nirenberg
D. watson and Crick
12
441RNA is more reactive than DNA. Why?12
442Which one is correctly matched with its specificity for an amino acid, start or stop in protein synthesis?
A. UCG – Start
B. UUU – Stop
c. UGU – Leucine
D. UAC – Tyrosine
12
443( mathbf{A} )
( 340 A ) long segment of DNA molecule
has 20 thymine nitrogenous bases, what will be the number of guanine nitrogen bases in the same segment?
A . 10
B . 40
c. 80
D. 160
12
444Similarity between DNA and RNA is that
both have
A. Similar sugars
B. Similar mode of replication
c. similar pyrimidines
D. Polymers of nucleotides
12
445What is true for E. coli with lac-z gene?
A. They cannot synthesize permease.
B. They cannot synthesize functional beta galactosidase.
C. They cannot synthesize transacetylase.
D. They cannot transport lactose from the medium into the cell.
12
446What is a genetic code?12
447Choose the correct answers from the
alternatives given If the sequence of bases in DNA is TAGC,
then the sequence of bases in RNA would be
A . AUCG
B. TAGC
c. АТСС
D. GCTA
12
448In Drosophila, a set of homeotic genes which control body plan at the time of organ differentiation is known as
A. TATA box
B. Homeobox
c. Pribnow box
D. All of the above
12

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